Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines
Identifieur interne : 000102 ( Main/Exploration ); précédent : 000101; suivant : 000103Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines
Auteurs : Laura Rodriguez ; Pilar Blanco-Lobo ; Emma C. Reilly [États-Unis] ; Tatsuya Maehigashi ; Aitor Nogales ; Andrew Smith [États-Unis] ; David J. Topham [États-Unis] ; Stephen Dewhurst ; Baek Kim [Corée du Sud] ; Luis Martínez-SobridoSource :
- Viruses [ 1999-4915 ] ; 2019.
Abstract
Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease. Two major types of influenza vaccines are approved for human use: inactivated influenza vaccines (IIVs) and live attenuated influenza vaccines (LAIVs). Two Master Donor Virus (MDV) backbones have been used to create LAIVs against influenza A virus (IAV): the United States (US) A/Ann Arbor/6/60 (AA) and the Russian A/Leningrad/134/17/57 (Len) H2N2 viruses. The mutations responsible for the temperature sensitive (
Url:
DOI: 10.3390/v11100928
PubMed: 31658679
PubMed Central: 6832241
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines</title><author><name sortKey="Rodriguez, Laura" sort="Rodriguez, Laura" uniqKey="Rodriguez L" first="Laura" last="Rodriguez">Laura Rodriguez</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Blanco Lobo, Pilar" sort="Blanco Lobo, Pilar" uniqKey="Blanco Lobo P" first="Pilar" last="Blanco-Lobo">Pilar Blanco-Lobo</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Reilly, Emma C" sort="Reilly, Emma C" uniqKey="Reilly E" first="Emma C." last="Reilly">Emma C. Reilly</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-viruses-11-00928">David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Maehigashi, Tatsuya" sort="Maehigashi, Tatsuya" uniqKey="Maehigashi T" first="Tatsuya" last="Maehigashi">Tatsuya Maehigashi</name><affiliation><nlm:aff id="af3-viruses-11-00928">Center for Drug Discovery, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, GA 30322, USA;<email>t.maehigashi@emory.edu</email> (T.M.);<email>baek.kim@emory.edu</email> (B.K.)</nlm:aff></affiliation></author><author><name sortKey="Nogales, Aitor" sort="Nogales, Aitor" uniqKey="Nogales A" first="Aitor" last="Nogales">Aitor Nogales</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Andrew" sort="Smith, Andrew" uniqKey="Smith A" first="Andrew" last="Smith">Andrew Smith</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-viruses-11-00928">Medical Scientist Training Program (MSTP), University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Scientist Training Program (MSTP), University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-viruses-11-00928">David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dewhurst, Stephen" sort="Dewhurst, Stephen" uniqKey="Dewhurst S" first="Stephen" last="Dewhurst">Stephen Dewhurst</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Kim, Baek" sort="Kim, Baek" uniqKey="Kim B" first="Baek" last="Kim">Baek Kim</name><affiliation><nlm:aff id="af3-viruses-11-00928">Center for Drug Discovery, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, GA 30322, USA;<email>t.maehigashi@emory.edu</email> (T.M.);<email>baek.kim@emory.edu</email> (B.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-viruses-11-00928">College of Pharmacy, Kyung-Hee University, Seoul 02447, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Kyung-Hee University, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31658679</idno><idno type="pmc">6832241</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832241</idno><idno type="RBID">PMC:6832241</idno><idno type="doi">10.3390/v11100928</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000C50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C50</idno><idno type="wicri:Area/Pmc/Curation">000C50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C50</idno><idno type="wicri:Area/Pmc/Checkpoint">000080</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000080</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:31658679</idno><idno type="wicri:Area/PubMed/Corpus">000005</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000005</idno><idno type="wicri:Area/PubMed/Curation">000005</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000005</idno><idno type="wicri:Area/PubMed/Checkpoint">000011</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000011</idno><idno type="wicri:Area/Ncbi/Merge">001019</idno><idno type="wicri:Area/Ncbi/Curation">001019</idno><idno type="wicri:Area/Ncbi/Checkpoint">001019</idno><idno type="wicri:Area/Main/Merge">000102</idno><idno type="wicri:Area/Main/Curation">000102</idno><idno type="wicri:Area/Main/Exploration">000102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines</title><author><name sortKey="Rodriguez, Laura" sort="Rodriguez, Laura" uniqKey="Rodriguez L" first="Laura" last="Rodriguez">Laura Rodriguez</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Blanco Lobo, Pilar" sort="Blanco Lobo, Pilar" uniqKey="Blanco Lobo P" first="Pilar" last="Blanco-Lobo">Pilar Blanco-Lobo</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Reilly, Emma C" sort="Reilly, Emma C" uniqKey="Reilly E" first="Emma C." last="Reilly">Emma C. Reilly</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-viruses-11-00928">David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Maehigashi, Tatsuya" sort="Maehigashi, Tatsuya" uniqKey="Maehigashi T" first="Tatsuya" last="Maehigashi">Tatsuya Maehigashi</name><affiliation><nlm:aff id="af3-viruses-11-00928">Center for Drug Discovery, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, GA 30322, USA;<email>t.maehigashi@emory.edu</email> (T.M.);<email>baek.kim@emory.edu</email> (B.K.)</nlm:aff></affiliation></author><author><name sortKey="Nogales, Aitor" sort="Nogales, Aitor" uniqKey="Nogales A" first="Aitor" last="Nogales">Aitor Nogales</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Andrew" sort="Smith, Andrew" uniqKey="Smith A" first="Andrew" last="Smith">Andrew Smith</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-viruses-11-00928">Medical Scientist Training Program (MSTP), University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Scientist Training Program (MSTP), University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-viruses-11-00928">David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dewhurst, Stephen" sort="Dewhurst, Stephen" uniqKey="Dewhurst S" first="Stephen" last="Dewhurst">Stephen Dewhurst</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author><author><name sortKey="Kim, Baek" sort="Kim, Baek" uniqKey="Kim B" first="Baek" last="Kim">Baek Kim</name><affiliation><nlm:aff id="af3-viruses-11-00928">Center for Drug Discovery, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, GA 30322, USA;<email>t.maehigashi@emory.edu</email> (T.M.);<email>baek.kim@emory.edu</email> (B.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-viruses-11-00928">College of Pharmacy, Kyung-Hee University, Seoul 02447, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Kyung-Hee University, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name><affiliation><nlm:aff id="af1-viruses-11-00928">Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA;<email>laurita85oviedo@hotmail.com</email> (L.R.);<email>piblanlo@gmail.com</email> (P.B.-L.);<email>emma_reilly@urmc.rochester.edu</email> (E.C.R.);<email>nogales.aitor@inia.es</email> (A.N.);<email>Andrew_Smith72@URMC.Rochester.edu</email> (A.S.);<email>David_topham@urmc.rochester.edu</email> (D.J.T.);<email>stephen_dewhurst@me.com</email> (S.D.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease. Two major types of influenza vaccines are approved for human use: inactivated influenza vaccines (IIVs) and live attenuated influenza vaccines (LAIVs). Two Master Donor Virus (MDV) backbones have been used to create LAIVs against influenza A virus (IAV): the United States (US) A/Ann Arbor/6/60 (AA) and the Russian A/Leningrad/134/17/57 (Len) H2N2 viruses. The mutations responsible for the temperature sensitive (<italic>ts</italic>), cold-adapted (<italic>ca</italic>) and attenuated (<italic>att</italic>) phenotypes of the two MDVs have been previously identified and genetically mapped. However, a direct comparison of the contribution of these residues to viral attenuation, immunogenicity and protection efficacy has not been conducted. Here, we compared the In vitro and in vivo phenotype of recombinant influenza A/Puerto Rico/8/34 H1N1 (PR8) viruses containing the <italic>ts, ca</italic> and <italic>att</italic> mutations of the US (PR8/AA) and the Russian (PR8/Len) MDVs. Our results show that PR8/Len is more attenuated in vivo than PR8/AA, although both viruses induced similar levels of humoral and cellular responses, and protection against homologous and heterologous viral challenges. Our findings support the feasibility of using a different virus backbone as MDV for the development of improved LAIVs for the prevention of IAV infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lynch, J P" uniqKey="Lynch J">J.P. Lynch</name></author><author><name sortKey="Walsh, E E" uniqKey="Walsh E">E.E. Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barr, I G" uniqKey="Barr I">I.G. Barr</name></author><author><name sortKey="Mccauley, J" uniqKey="Mccauley J">J. McCauley</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Daniels, R" uniqKey="Daniels R">R. Daniels</name></author><author><name sortKey="Engelhardt, O G" uniqKey="Engelhardt O">O.G. Engelhardt</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author><author><name sortKey="Grohmann, G" uniqKey="Grohmann G">G. Grohmann</name></author><author><name sortKey="Hay, A" uniqKey="Hay A">A. Hay</name></author><author><name sortKey="Kelso, A" uniqKey="Kelso A">A. Kelso</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A. Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, G J" uniqKey="Smith G">G.J. Smith</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D. Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J. Bahl</name></author><author><name sortKey="Lycett, S J" uniqKey="Lycett S">S.J. Lycett</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M. Worobey</name></author><author><name sortKey="Pybus, O G" uniqKey="Pybus O">O.G. Pybus</name></author><author><name sortKey="Ma, S K" uniqKey="Ma S">S.K. Ma</name></author><author><name sortKey="Cheung, C L" uniqKey="Cheung C">C.L. Cheung</name></author><author><name sortKey="Raghwani, J" uniqKey="Raghwani J">J. Raghwani</name></author><author><name sortKey="Bhatt, S" uniqKey="Bhatt S">S. Bhatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pica, N" uniqKey="Pica N">N. Pica</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belongia, E A" uniqKey="Belongia E">E.A. Belongia</name></author><author><name sortKey="Kieke, B A" uniqKey="Kieke B">B.A. Kieke</name></author><author><name sortKey="Donahue, J G" uniqKey="Donahue J">J.G. Donahue</name></author><author><name sortKey="Greenlee, R T" uniqKey="Greenlee R">R.T. Greenlee</name></author><author><name sortKey="Balish, A" uniqKey="Balish A">A. Balish</name></author><author><name sortKey="Foust, A" uniqKey="Foust A">A. Foust</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S. Lindstrom</name></author><author><name sortKey="Shay, D K" uniqKey="Shay D">D.K. Shay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, M T" uniqKey="Osterholm M">M.T. Osterholm</name></author><author><name sortKey="Kelley, N S" uniqKey="Kelley N">N.S. Kelley</name></author><author><name sortKey="Sommer, A" uniqKey="Sommer A">A. Sommer</name></author><author><name sortKey="Belongia, E A" uniqKey="Belongia E">E.A. Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, M M" uniqKey="Cox M">M.M. Cox</name></author><author><name sortKey="Patriarca, P A" uniqKey="Patriarca P">P.A. Patriarca</name></author><author><name sortKey="Treanor, J" uniqKey="Treanor J">J. Treanor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P S" uniqKey="Palese P">P.S. Palese</name></author><author><name sortKey="Megan, L" uniqKey="Megan L">L. Megan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoft, D F" uniqKey="Hoft D">D.F. Hoft</name></author><author><name sortKey="Babusis, E" uniqKey="Babusis E">E. Babusis</name></author><author><name sortKey="Worku, S" uniqKey="Worku S">S. Worku</name></author><author><name sortKey="Spencer, C T" uniqKey="Spencer C">C.T. Spencer</name></author><author><name sortKey="Lottenbach, K" uniqKey="Lottenbach K">K. Lottenbach</name></author><author><name sortKey="Truscott, S M" uniqKey="Truscott S">S.M. Truscott</name></author><author><name sortKey="Abate, G" uniqKey="Abate G">G. Abate</name></author><author><name sortKey="Sakala, I G" uniqKey="Sakala I">I.G. Sakala</name></author><author><name sortKey="Edwards, K M" uniqKey="Edwards K">K.M. Edwards</name></author><author><name sortKey="Creech, C B" uniqKey="Creech C">C.B. Creech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Chauche, C" uniqKey="Chauche C">C. Chauche</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K. Huang</name></author><author><name sortKey="Reilly, E C" uniqKey="Reilly E">E.C. Reilly</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Murcia, P R" uniqKey="Murcia P">P.R. Murcia</name></author><author><name sortKey="Parrish, C R" uniqKey="Parrish C">C.R. Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Reilly, E C" uniqKey="Reilly E">E.C. Reilly</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Murcia, P R" uniqKey="Murcia P">P.R. Murcia</name></author><author><name sortKey="Parrish, C R" uniqKey="Parrish C">C.R. Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Reedy, S" uniqKey="Reedy S">S. Reedy</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Murcia, P R" uniqKey="Murcia P">P.R. Murcia</name></author><author><name sortKey="Chambers, T M" uniqKey="Chambers T">T.M. Chambers</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maassab, H F" uniqKey="Maassab H">H.F. Maassab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aleksandrova, G I" uniqKey="Aleksandrova G">G.I. Aleksandrova</name></author><author><name sortKey="Mikutskaia, B A" uniqKey="Mikutskaia B">B.A. Mikutskaia</name></author><author><name sortKey="Pleshanova, R A" uniqKey="Pleshanova R">R.A. Pleshanova</name></author><author><name sortKey="Panova, N G" uniqKey="Panova N">N.G. Panova</name></author><author><name sortKey="Smorodintsev, A A" uniqKey="Smorodintsev A">A.A. Smorodintsev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, W D" uniqKey="Wilson W">W.D. Wilson</name></author><author><name sortKey="Robinson, D" uniqKey="Robinson D">D. Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Youngner, J S" uniqKey="Youngner J">J.S. Youngner</name></author><author><name sortKey="Whitaker Dowling, P" uniqKey="Whitaker Dowling P">P. Whitaker-Dowling</name></author><author><name sortKey="Chambers, T M" uniqKey="Chambers T">T.M. Chambers</name></author><author><name sortKey="Rushlow, K E" uniqKey="Rushlow K">K.E. Rushlow</name></author><author><name sortKey="Sebring, R" uniqKey="Sebring R">R. Sebring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, W" uniqKey="Chan W">W. Chan</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H. Zhou</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G. Kemble</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Coelingh, K" uniqKey="Coelingh K">K. Coelingh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohlmeier, J E" uniqKey="Kohlmeier J">J.E. Kohlmeier</name></author><author><name sortKey="Woodland, D L" uniqKey="Woodland D">D.L. Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Murcia, P R" uniqKey="Murcia P">P.R. Murcia</name></author><author><name sortKey="Parrish, C R" uniqKey="Parrish C">C.R. Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, X" uniqKey="Cheng X">X. Cheng</name></author><author><name sortKey="Zengel, J R" uniqKey="Zengel J">J.R. Zengel</name></author><author><name sortKey="Suguitan, A L" uniqKey="Suguitan A">A.L. Suguitan</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q. Xu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Victor, S T" uniqKey="Victor S">S.T. Victor</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S. Watanabe</name></author><author><name sortKey="Katsura, H" uniqKey="Katsura H">H. Katsura</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M. Ozawa</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Villiers, P J" uniqKey="De Villiers P">P.J. De Villiers</name></author><author><name sortKey="Steele, A D" uniqKey="Steele A">A.D. Steele</name></author><author><name sortKey="Hiemstra, L A" uniqKey="Hiemstra L">L.A. Hiemstra</name></author><author><name sortKey="Rappaport, R" uniqKey="Rappaport R">R. Rappaport</name></author><author><name sortKey="Dunning, A J" uniqKey="Dunning A">A.J. Dunning</name></author><author><name sortKey="Gruber, W C" uniqKey="Gruber W">W.C. Gruber</name></author><author><name sortKey="Forrest, B D" uniqKey="Forrest B">B.D. Forrest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, S F" uniqKey="Baker S">S.F. Baker</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name></author><author><name sortKey="Albrecht, R A" uniqKey="Albrecht R">R.A. Albrecht</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powell, T J" uniqKey="Powell T">T.J. Powell</name></author><author><name sortKey="Silk, J D" uniqKey="Silk J">J.D. Silk</name></author><author><name sortKey="Sharps, J" uniqKey="Sharps J">J. Sharps</name></author><author><name sortKey="Fodor, E" uniqKey="Fodor E">E. Fodor</name></author><author><name sortKey="Townsend, A R" uniqKey="Townsend A">A.R. Townsend</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uraki, R" uniqKey="Uraki R">R. Uraki</name></author><author><name sortKey="Kiso, M" uniqKey="Kiso M">M. Kiso</name></author><author><name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K. Iwatsuki-Horimoto</name></author><author><name sortKey="Fukuyama, S" uniqKey="Fukuyama S">S. Fukuyama</name></author><author><name sortKey="Takashita, E" uniqKey="Takashita E">E. Takashita</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M. Ozawa</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsura, H" uniqKey="Katsura H">H. Katsura</name></author><author><name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K. Iwatsuki-Horimoto</name></author><author><name sortKey="Fukuyama, S" uniqKey="Fukuyama S">S. Fukuyama</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S. Watanabe</name></author><author><name sortKey="Sakabe, S" uniqKey="Sakabe S">S. Sakabe</name></author><author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y. Hatta</name></author><author><name sortKey="Murakami, S" uniqKey="Murakami S">S. Murakami</name></author><author><name sortKey="Shimojima, M" uniqKey="Shimojima M">M. Shimojima</name></author><author><name sortKey="Horimoto, T" uniqKey="Horimoto T">T. Horimoto</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rudenko, L" uniqKey="Rudenko L">L. Rudenko</name></author><author><name sortKey="Yeolekar, L" uniqKey="Yeolekar L">L. Yeolekar</name></author><author><name sortKey="Kiseleva, I" uniqKey="Kiseleva I">I. Kiseleva</name></author><author><name sortKey="Isakova Sivak, I" uniqKey="Isakova Sivak I">I. Isakova-Sivak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, N J" uniqKey="Cox N">N.J. Cox</name></author><author><name sortKey="Kitame, F" uniqKey="Kitame F">F. Kitame</name></author><author><name sortKey="Kendal, A P" uniqKey="Kendal A">A.P. Kendal</name></author><author><name sortKey="Maassab, H F" uniqKey="Maassab H">H.F. Maassab</name></author><author><name sortKey="Naeve, C" uniqKey="Naeve C">C. Naeve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, M H" uniqKey="Snyder M">M.H. Snyder</name></author><author><name sortKey="Betts, R F" uniqKey="Betts R">R.F. Betts</name></author><author><name sortKey="Deborde, D" uniqKey="Deborde D">D. DeBorde</name></author><author><name sortKey="Tierney, E L" uniqKey="Tierney E">E.L. Tierney</name></author><author><name sortKey="Clements, M L" uniqKey="Clements M">M.L. Clements</name></author><author><name sortKey="Herrington, D" uniqKey="Herrington D">D. Herrington</name></author><author><name sortKey="Sears, S D" uniqKey="Sears S">S.D. Sears</name></author><author><name sortKey="Dolin, R" uniqKey="Dolin R">R. Dolin</name></author><author><name sortKey="Maassab, H F" uniqKey="Maassab H">H.F. Maassab</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Isakova Sivak, I" uniqKey="Isakova Sivak I">I. Isakova-Sivak</name></author><author><name sortKey="Chen, L M" uniqKey="Chen L">L.M. Chen</name></author><author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y. Matsuoka</name></author><author><name sortKey="Voeten, J T" uniqKey="Voeten J">J.T. Voeten</name></author><author><name sortKey="Kiseleva, I" uniqKey="Kiseleva I">I. Kiseleva</name></author><author><name sortKey="Heldens, J G" uniqKey="Heldens J">J.G. Heldens</name></author><author><name sortKey="Den Bosch, H" uniqKey="Den Bosch H">H. den Bosch</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A. Klimov</name></author><author><name sortKey="Rudenko, L" uniqKey="Rudenko L">L. Rudenko</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N.J. Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, A" uniqKey="Cox A">A. Cox</name></author><author><name sortKey="Baker, S F" uniqKey="Baker S">S.F. Baker</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S. Dewhurst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H. Zhou</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B. Lu</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G. Kemble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B. Zhou</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Speer, S D" uniqKey="Speer S">S.D. Speer</name></author><author><name sortKey="Subba, A" uniqKey="Subba A">A. Subba</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name></author><author><name sortKey="Wentworth, D E" uniqKey="Wentworth D">D.E. Wentworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broadbent, A J" uniqKey="Broadbent A">A.J. Broadbent</name></author><author><name sortKey="Santos, C P" uniqKey="Santos C">C.P. Santos</name></author><author><name sortKey="Godbout, R A" uniqKey="Godbout R">R.A. Godbout</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Czako, R" uniqKey="Czako R">R. Czako</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Sutton, T" uniqKey="Sutton T">T. Sutton</name></author><author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y. Matsuoka</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Baz, M" uniqKey="Baz M">M. Baz</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name></author><author><name sortKey="Paskel, M" uniqKey="Paskel M">M. Paskel</name></author><author><name sortKey="Santos, C" uniqKey="Santos C">C. Santos</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author><author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y. Matsuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Talaat, K" uniqKey="Talaat K">K. Talaat</name></author><author><name sortKey="Karron, R" uniqKey="Karron R">R. Karron</name></author><author><name sortKey="Powell, T J" uniqKey="Powell T">T.J. Powell</name></author><author><name sortKey="Zeng, H" uniqKey="Zeng H">H. Zeng</name></author><author><name sortKey="Dong, D" uniqKey="Dong D">D. Dong</name></author><author><name sortKey="Luke, C J" uniqKey="Luke C">C.J. Luke</name></author><author><name sortKey="Mcmichael, A" uniqKey="Mcmichael A">A. McMichael</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimm, D" uniqKey="Grimm D">D. Grimm</name></author><author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P. Staeheli</name></author><author><name sortKey="Hufbauer, M" uniqKey="Hufbauer M">M. Hufbauer</name></author><author><name sortKey="Koerner, I" uniqKey="Koerner I">I. Koerner</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Solorzano, A" uniqKey="Solorzano A">A. Solorzano</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Haller, O" uniqKey="Haller O">O. Haller</name></author><author><name sortKey="Kochs, G" uniqKey="Kochs G">G. Kochs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, E D" uniqKey="Kilbourne E">E.D. Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Baker, S F" uniqKey="Baker S">S.F. Baker</name></author><author><name sortKey="Ortiz Riano, E" uniqKey="Ortiz Riano E">E. Ortiz-Riano</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S. Dewhurst</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schickli, J H" uniqKey="Schickli J">J.H. Schickli</name></author><author><name sortKey="Flandorfer, A" uniqKey="Flandorfer A">A. Flandorfer</name></author><author><name sortKey="Nakaya, T" uniqKey="Nakaya T">T. Nakaya</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L. Rodriguez</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, L J" uniqKey="Reed L">L.J. Reed</name></author><author><name sortKey="Muench, H" uniqKey="Muench H">H. Muench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name></author><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reilly, E C" uniqKey="Reilly E">E.C. Reilly</name></author><author><name sortKey="Lambert Emo, K" uniqKey="Lambert Emo K">K. Lambert-Emo</name></author><author><name sortKey="Topham, D J" uniqKey="Topham D">D.J. Topham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belshe, R" uniqKey="Belshe R">R. Belshe</name></author><author><name sortKey="Lee, M S" uniqKey="Lee M">M.S. Lee</name></author><author><name sortKey="Walker, R E" uniqKey="Walker R">R.E. Walker</name></author><author><name sortKey="Stoddard, J" uniqKey="Stoddard J">J. Stoddard</name></author><author><name sortKey="Mendelman, P M" uniqKey="Mendelman P">P.M. Mendelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belshe, R B" uniqKey="Belshe R">R.B. Belshe</name></author><author><name sortKey="Edwards, K M" uniqKey="Edwards K">K.M. Edwards</name></author><author><name sortKey="Vesikari, T" uniqKey="Vesikari T">T. Vesikari</name></author><author><name sortKey="Black, S V" uniqKey="Black S">S.V. Black</name></author><author><name sortKey="Walker, R E" uniqKey="Walker R">R.E. Walker</name></author><author><name sortKey="Hultquist, M" uniqKey="Hultquist M">M. Hultquist</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G. Kemble</name></author><author><name sortKey="Connor, E M" uniqKey="Connor E">E.M. Connor</name></author><author><name sortKey="Group, C T C E S" uniqKey="Group C">C.T.C.E.S. Group</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorse, G J" uniqKey="Gorse G">G.J. Gorse</name></author><author><name sortKey="Belshe, R B" uniqKey="Belshe R">R.B. Belshe</name></author><author><name sortKey="Munn, N J" uniqKey="Munn N">N.J. Munn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudenko, L G" uniqKey="Rudenko L">L.G. Rudenko</name></author><author><name sortKey="Slepushkin, A N" uniqKey="Slepushkin A">A.N. Slepushkin</name></author><author><name sortKey="Monto, A S" uniqKey="Monto A">A.S. Monto</name></author><author><name sortKey="Kendal, A P" uniqKey="Kendal A">A.P. Kendal</name></author><author><name sortKey="Grigorieva, E P" uniqKey="Grigorieva E">E.P. Grigorieva</name></author><author><name sortKey="Burtseva, E P" uniqKey="Burtseva E">E.P. Burtseva</name></author><author><name sortKey="Rekstin, A R" uniqKey="Rekstin A">A.R. Rekstin</name></author><author><name sortKey="Beljaev, A L" uniqKey="Beljaev A">A.L. Beljaev</name></author><author><name sortKey="Bragina, V E" uniqKey="Bragina V">V.E. Bragina</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slepushkin, A N" uniqKey="Slepushkin A">A.N. Slepushkin</name></author><author><name sortKey="Obrosova Serova, N P" uniqKey="Obrosova Serova N">N.P. Obrosova-Serova</name></author><author><name sortKey="Burtseva, E I" uniqKey="Burtseva E">E.I. Burtseva</name></author><author><name sortKey="Rudenko, L G" uniqKey="Rudenko L">L.G. Rudenko</name></author><author><name sortKey="Govorkova, E A" uniqKey="Govorkova E">E.A. Govorkova</name></author><author><name sortKey="Vartanyan, R V" uniqKey="Vartanyan R">R.V. Vartanyan</name></author><author><name sortKey="Verestsinsky, A I" uniqKey="Verestsinsky A">A.I. Verestsinsky</name></author><author><name sortKey="Lonskaya, N I" uniqKey="Lonskaya N">N.I. Lonskaya</name></author><author><name sortKey="Harmon, M W" uniqKey="Harmon M">M.W. Harmon</name></author><author><name sortKey="Torok, T" uniqKey="Torok T">T. Torok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lukarska, M" uniqKey="Lukarska M">M. Lukarska</name></author><author><name sortKey="Fournier, G" uniqKey="Fournier G">G. Fournier</name></author><author><name sortKey="Pflug, A" uniqKey="Pflug A">A. Pflug</name></author><author><name sortKey="Resa Infante, P" uniqKey="Resa Infante P">P. Resa-Infante</name></author><author><name sortKey="Reich, S" uniqKey="Reich S">S. Reich</name></author><author><name sortKey="Naffakh, N" uniqKey="Naffakh N">N. Naffakh</name></author><author><name sortKey="Cusack, S" uniqKey="Cusack S">S. Cusack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delano, W L" uniqKey="Delano W">W.L. DeLano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Région capitale de Séoul</li><li>État de New York</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Blanco Lobo, Pilar" sort="Blanco Lobo, Pilar" uniqKey="Blanco Lobo P" first="Pilar" last="Blanco-Lobo">Pilar Blanco-Lobo</name><name sortKey="Dewhurst, Stephen" sort="Dewhurst, Stephen" uniqKey="Dewhurst S" first="Stephen" last="Dewhurst">Stephen Dewhurst</name><name sortKey="Maehigashi, Tatsuya" sort="Maehigashi, Tatsuya" uniqKey="Maehigashi T" first="Tatsuya" last="Maehigashi">Tatsuya Maehigashi</name><name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name><name sortKey="Nogales, Aitor" sort="Nogales, Aitor" uniqKey="Nogales A" first="Aitor" last="Nogales">Aitor Nogales</name><name sortKey="Rodriguez, Laura" sort="Rodriguez, Laura" uniqKey="Rodriguez L" first="Laura" last="Rodriguez">Laura Rodriguez</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Reilly, Emma C" sort="Reilly, Emma C" uniqKey="Reilly E" first="Emma C." last="Reilly">Emma C. Reilly</name></region><name sortKey="Smith, Andrew" sort="Smith, Andrew" uniqKey="Smith A" first="Andrew" last="Smith">Andrew Smith</name><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Baek" sort="Kim, Baek" uniqKey="Kim B" first="Baek" last="Kim">Baek Kim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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